Upstate NY LRIG's Blog

Upstate NY LRIG Meeting…SAVE THE DATE !!!

upstatenylrig — Thu, 12 Aug 2010 17:54:37 +0000

Monday, November 8th with distingushed guest speaker Dr. Pankaj Karande

Conference Topic is HIGH THROUGH-PUT AUTOMATION

More details to follow at:

http://lab-robotics.org/Upstate/

Help your Chemists Make Better Compounds

upstatenylrig — Wed, 28 Jul 2010 17:26:20 +0000

Help your Chemists Make Better Compounds

Personalized Kinase Profiling Plates Are Just a Click Away
With the LabChip EZ Reader and Personalized ProfilerPro Kinase Assay Kits

Personalized Plates available in 12 plate small batch program
Order your personalized kinase profiling group TODAY!

Provide your chemists with the highest quality data from your personalized kinase selectivity
profile in ONE DAY.

Advantages of the Personalized ProfilerPro kits include:

YOU select which kinases are important for your profiles. Select from over 200 kinases
representing broad kinome coverage, and map them into your personalized plate format.

Best-in-class mobility shift technology assays. Enables measurement of both substrate
and product which gives high quality data without compound interference and false positives.

Greatly impacts your medicinal chemistry programs by returning data in as little as ONE DAY.

Click here for details on ProfilerPro Kits or email us for more information.

Microfluidics LabChip Platform for Vaccines & Biologics

upstatenylrig — Tue, 27 Jul 2010 17:36:55 +0000

LabChip^® GXII Technology for Vaccines and Biologics
“10X Increase in Yield possible due to high throughput expression monitoring.”
Dow/Pfenex Subunit Vaccine

In the field of Vaccines and Biologics, the LabChip GXII has been widely adopted across the Discovery and Development pipeline by a large number of pharmaceutical and vaccine developers to improve their analytical capabilities for protein therapeutics and vaccines.

The LabChip performs rapid quantitative assessments of size, purity and titer, directly from 96- and 384-well plates and is applicable to vaccine strain development, protein subunit expression optimization, vaccine formulation development & stability, and QC methods development & QA.

Protein Analysis

Recombinant Subunit Expression Optimization and Tracking

Subunit Purification Tracking

Formulation Development – Excipient Assessment, Purity, Stability, Modification, Aggregation, Degradation

Product Quality Assessment – Purity, Stability, Modification, Aggregation, Degradation

Virus Like Particle (VLP) Characterization

Glycan Analysis

Identification of main glycans

Analysis is 60 seconds per sample

Less than 6 hours from prep to final analysis for 96 samples

Reagents provided in a convenient 96-well plate format

Click here for more information on the LabChip GX system for vaccines & biologics.

Customer Quotes about the LabChip GXII platform for vaccines and biologics:“Screen the performance of pharmaceutical excipients. The LabChip GXII is used to monitor the chemical and physical stability of the antigen within complex matrix of excipients, before and after stress.” Scientist, R&D Formulation Development, Belgium

“LabChip enables us to perform experiments in an afternoon that would have required a month.”
Biogen-Idec, COG 2009

“Finally, the process that we have described reduces both experimentation cost and time while increasing throughput, making possible what–if experiments that, up to now, had been either prohibitively expensive or too complex to perform. This process results in better solutions, decreased development time and increased productivity.” Vertex, Anal. Biochem.
2006:351 p122

“Expression screen by magnetic bead purification and Caliper LabChip gives objective and quantifiable results.” Boehringer Ingelheim, Global Protein Summit, London, 2006

Caliper Life Sciences Launches LabChip XT for Next Generation Sequencing Applications

upstatenylrig — Tue, 06 Jul 2010 20:39:07 +0000

Caliper, a leading provider of tools and services for drug discovery and life sciences research, today introduced the LabChip XT, an automated nucleic acid fractionation instrument. The solution removes a key bottleneck in the current workflow for next generation sequencing by replacing the tedious gel isolation and purification steps used for size selection of sheared genomic DNA. The LabChip XT and its integrated software utilize a multi-channel microfluidic chip to quickly process samples independently and without the potential for cross contamination. “The LabChip XT was developed in collaboration with leading sequencing centers and providers of next generation sequencing instrumentation and chemistries,” said Kevin Hrusovsky, President and CEO, Caliper Life Sciences. “We are confident that the LabChip XT, the first product Caliper is introducing to the sequencing market, will improve sample preparation efficiency and downstream data processing—two critical elements for next-gen sequencing. We are collaborating with our newly formed Sequencing Science Advisory Board to demonstrate these sequencing workflow improvements as well as to develop additional technology platforms in this sector.”

For more information, please visit our web-site at www.caliperls.com

Invitation to Caliper Owner’s Group (COG) meeting and open house June 9th & 10th

upstatenylrig — Mon, 26 Apr 2010 12:51:13 +0000

Dear Upstate NY LRIG Members,

On behalf of myself and the 400+ employees at Caliper Life Sciences I would like to invite you to attend our Caliper Owner’s Group (COG) meeting and open house. Last year’s events were a huge success and we had fantastic presentations from over 70 customers. This year we are expecting presentations from Pfizer, Merck, Novartis, Roche, BMS, Abbott, Amgen, Biogen, Wyeth, Dow, Broad, JGI, FDA, NCI and many others. We also expect several important life sciences collaborators to potentially present in the genomics application segment such as Illumina, Ion Torrent, Pac Bio, Fluidigm, and Life.

We have an exciting program planned for COG 2010 and look forward to your participation. This year’s meeting is divided into four parallel application tracks (Biologics/Vaccines, Optical Imaging, Genomics, and Small Molecules) and will include presentations and insights by customers leveraging Caliper’s suite of technologies in relevant application areas.

Biologics/Vaccines
Presentations focused on the use of Caliper’s LabChip GX and automation systems in the production and QC of biologics and vaccines. Presentations will include perspectives from both development and production, and highlight the application of the GX’s protein and glycan assays.

Optical Imaging
This track is focused on cutting edge methods and applications of Caliper’s optical imaging IVIS technology. It will include presentations covering stem cell, CNS, oncology, infectious disease research and more.

Genomics
Track will include presentations on the application of the LabChip GX in genomic workflows, with emphasis on next generation sequencing, genotyping, and molecular diagnostics. The genomics track will also include presentations on Caliper’s recently launched LabChip XT, an advanced solution for nucleic acid fractionation and collection.

Small Molecule Drug Discovery
Presentations will focus on the application of Caliper’s microfluidics platform for compound screening, profiling and mechanism of action studies as well as automated robotic systems for ADME Tox and other discovery applications.

We have expanded this year’s program and will be taking our COG meetings on the road globally for 2010. We have planned meetings in San Francisco and San Diego as well as Hopkinton, and will announce dates for the international meetings, as they are confirmed. Please click on the link below for dates and to register.

www.caliperls.com/COG2010

Thank you for again, and I look forward to seeing you at COG 2010.

Best regards,
Kevin

Kevin Hrusovsky
President & CEO
Caliper Life Sciences

Dr. Steven Fillers now compliments Caliper Life Sciences team !

upstatenylrig — Mon, 26 Apr 2010 12:46:42 +0000

We are proud to introduce the newest member complimenting the Caliper Life Sciences team, Dr. Steven Fillers. Steven brings more than 25 years of experience in developing robotics systems applied to scientific research, clinical diagnostics, and sample management. Steven is the founder and President of L.R.I.G. ( Laboratory Robotics Interest Group. ) Additionally he has served on automation related committees for the SBS, ALA and Miptec organizations and is currently a member of the Editorial Board for JALA. We wish Steven all the best !

Art Robbins Instruments: PHOENIX or GRYPHON Liquid Handling System

upstatenylrig — Fri, 22 Jan 2010 22:08:07 +0000

PHOENIX or GRYPHON

Liquid Handling System

Fast…Accurate…Precise….Reliable

The Phoenix Liquid Handling System

The Phoenix is a 9 position, high-throughput liquid-handling platform used around the world that incorporates a space-saving design with flexible dispensing options. The competitively priced Phoenix provides increased efficiency and cost-effectiveness. It is designed to meet the demanding requirements of protein crystallography, high throughput screening and genomics laboratories. This unique instrument combines the precise low-volume dispensing capabilities of a syringe head with an on-the-fly non-contact nano dispenser.

Gryphon Liquid Handling System

Features:

Interchangeable heads: 96 or 384 flexible needle syringe or pipette tip

Base unit includes touch screen interface for easy control and integrated wash system in a small 9 x16 x 25 (W x D x H) inch foot print.

Optional X-Y stage includes easy to use Windows based software in a small 21 x 21 inch foot print.

Optional non-contact nano dispenser makes an ideal configuration for protein crystallization assays.

Specifications:

Software requires Windows dotNet. 120/240 VAC

Visit our website at www.artrobbins.us

Caliper Integrated System Cited as #4 on the list of TIME Magazine’s Top Ten Scientific Discoveries list for 2009!

upstatenylrig — Thu, 21 Jan 2010 18:27:40 +0000

For more on this amazing story, please Click Here.

GPCR assays and services provided by Euroscreen FAST

upstatenylrig — Wed, 20 Jan 2010 18:23:14 +0000

Euroscreen FAST (www.euroscreen-fast.com) provides customers high quality GPCR service capabilities with a dedicated service for flexibility and high quality at competitive pricing. Our extensive GPCR services platform includes:

The largest catalogue for GPCR assays (http://www.euroscreen.com/pdfs/catalog.pdf) which has more than 50 new assays.
Unique expertise for specific assay development fitting with your specific projects
HTS platform suitable for functional and radiolabeled screening of customer’s, third party or Euroscreen libraries
Lead identification and optimization testing with weekly testing
Functional profiling of GPCRs with updated diversity profile at very attractive pricing, and a full panel of human metabotropic glutamate receptors for profiling
Performing deorphanization platform with a successful track record and collection of most human orphan GPCRs ready for screening

As of January 11, 2010, Euroscreen FAST has resumed its cell line business and is selling new cell lines to customers. Cell lines are validated in an assay for you as well.

IEEE 6th International Conference Update:

upstatenylrig — Wed, 06 Jan 2010 16:13:27 +0000

The program committee for the IEEE 6^th International Conference on Automation Science and Engineering (CASE: August 22-24, 2010) is actively seeking proposals for special sessions at the conference. If you or your company is interested in participating in a special session in High-Throughput Screening, Drug Discovery, Automated Cell Culturing, Forensics, Bioinformatics or another topic in life science automation, please contact the CASE program chair Yu Sun (sun@mie.utoronto.ca) or the Upstate New York LRIG (LRIG.Tech.Valley@lab-robotics.org ). The deadline for special session proposals is February 1, 2010.